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Ipamorelin: selective GHS-R1a agonist minimal cortisol, prolactin, or appetite effects GHRP-6: GHS-R1a agonist with additional CRH/ACTH activation, prolactin release, and potent orexigenic activity Ipamorelin selectivity ratio (GH:cortisol) is among the highest of all synthetic GHRPs GHRP-6 was instrumental in GHS-R1a receptor identification but is pharmacologically non-selective GH Release Profiles & Pulse Amplitude Both ipamorelin and GHRP-6 stimulate pulsatile GH release from anterior pituitary somatotrophs via GHS-R1a activation, working synergistically with endogenous GHRH

doi: 10.1038/s12276-022-00811-2 115 ChenTLinYWuZShiHHuWLiSet al

Taking higher doses than prescribed

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Your healthcare provider at PlexusDx can discuss your specific situation, but deviating from the established protocol increases the chance of side effects without enhancing weight loss

This individualized approach prevents unnecessary escalation and unnecessary side effect burden