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Week 7-8 (or 13-16): For persistent poor responders, consider final increase to 450-500mcg nightly, though additional benefit often minimal

The "sip and go" idea reflects a highly practical morning routine for many people: take the tablet the exact moment you wake up, then by the time you have showered, brushed your teeth, and got dressed, you can eat breakfast and most of the medicine will have been successfully absorbed

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