Smith Jr has no conflicts relevant to the content of the review article
25,26 These studies provided evidence that, although TMAO is generated in the liver, this metabolite can in turn act on the hepatocytes and exert systemic influence
Slow the progression of kidney disease Chronic kidney disease is a frequent complication of uncontrolled diabetes
There are also single reports that a disorder of local (rather than plasma) lipoprotein metabolism in the central nervous system and cerebrospinal fluid is most likely the cause of decreased supply of cholesterol necessary for the recovery of myelin sheaths, which is probably associated with neurodegenerative diseases [382]
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