Lilly is studying retatrutide in several Phase 3 clinical trials to evaluate its potential efficacy and safety in obesity and overweight with at least one weight-related medical problem, type 2 diabetes, knee osteoarthritis, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes and metabolic dysfunction-associated steatotic liver disease
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Pancreatic concerns All GLP-1 receptor agonists carry theoretical concerns about pancreatitis and pancreatic cancer risk
International sources, particularly direct manufacturers, can offer lower pricing but require more due diligence and carry customs seizure risk
10.1038/s41591-021-01425-3 [DOI] [PubMed] [Google Scholar] 17.Loomba, R
By harnessing the power of a GLP-1, GIP, and glucagon receptor agonist simultaneously, this medication is being studied for effects on appetite, metabolic signaling, and energy balance