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Today, there is no scientific evidence that this happens, but a related drug in the class, tirzepatide (Mounjaro, Zepbound), carries warnings on its FDA labels that it may reduce the efficacy of oral hormonal contraceptives due to delayed gastric emptying. Patients are advised to switch to a non-oral form of contraception or to add a barrier method, such as condoms

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A tale of two endings: modulation of satiation by NMDA receptors on or near central and peripheral vagal afferent terminals