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18 , 25 , 26 Modified Ringer's solution (140 mM NaCl, 1.2 mM CaCl 2 , 3.0 mM KCl, 1.0 mM MgCl 2

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The work described below is aimed at addressing these outstanding questions to better understand brain bioenergetic changes that precede AD pathology

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2 Methods 2.1 Data source This study utilized data from the TriNetX US Collaborative Network, a comprehensive real-world data platform that aggregates information from 66 healthcare organizations, including academic medical centers, community hospitals, and large integrated healthcare systems