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Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein

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Depletion of intracellular glutathione (GSH) markedly promotes mitochondrial ROS production and triggers mitochondrial membrane depolarization (Lohan et al., 2018)

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Other participants in the TCA cycle are also more active in KRAS-mutant tumors, particularly in pancreatic ductal adenocarcinoma (PDAC), where the increased expression of GOT1/2 supports glutamine metabolism while producing NADPH to maintain REDOX balance [50]