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Deletion of the gene encoding ABCA1, responsible for lipidating ApoE in the CNS, resulted in an increase in A deposition (Wahrle et al., 2005) Conversely, overexpression of ABCA1 resulted in a decrease in A deposition (Wahrle et al., 2008) in amyloid mouse models, suggesting that increasing ApoE lipidation can reduce A pathology

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Researchers should note that this body of evidence derives predominantly from animal models, and independent replication remains more limited than in some other research areas

10.1111/ijd.13931 52 DivanbeygikermaniM.PardakhtyA.AmanatfardA