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It also needs to be clearly stated that GLP-1 RAs have multiple AEs and safety concerns, which reduce acceptability and have been difficult to access for eligible persons due to acquisition cost barriers

5.7 Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, when used in combination with insulin

No significant improvement in cellular physiologic status was observed in pancreas, liver, gall bladder and intestines in Cohort 2

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doi: 10.2337/dc24-1678 7 PopoviciuM-SPduraruLYahyaGMetwallyKCavaluS

Reducing Excess Body Fat Another key age-related change is increased body fat, particularly around the midsection