As a member of the killer immunoglobulin-like receptor family, KIR2DS4 is an activating receptor on NK cells that modulates their cytotoxic response (4850)
Kong et al., similarly uncovered synergy between a complex I inhibitor and a mito-antioxidant in cancer cells, suggesting their ability to reduce mitochondria-derived H 2 O 2 levels as a potential mechanism of action (28)
doi:10.1371/journal.pone.0215815 9
Its a small win that compounds into long-term health
VIP and immune cell modulation VIP interacts with multiple immune cells through specific receptors (VPAC-1, VPAC-2, CRTH2, and PAC1) expressed on eosinophils, mast cells, neutrophils, lymphocytes, dendritic cells, NK cells, and macrophages
10.2215/CJN.00020122 102 TrujilloJ