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For breeding, male VE-Cadherin-Cre ERT2 mice were crossed with female Igf1r f/f mice to generate VE-Cadherin-Cre ERT2 /Igf1r + / males, which were subsequently bred with Igf1r f/f females to establish the VE-Cadherin-Cre ERT2 /IGF1R homozygous floxed founder colony, following our previously described protocol [17, 45]

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Cortes J, Kantarjian H, OBrien S, Beran M, Estey E, Koller C, Andreeff M , Kornblau S, Keating M, Freireich EJ, Talpaz M