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Hydroxy B12 is considered one of the most well-tolerated forms of vitamin B12, offering sustained release and potentially longer-lasting benefits compared to other forms like cyanocobalamin

For gut issues, oral capsules work well at 500-1,000mcg daily on an empty stomach

The mechanism involves protecting neuronal mitochondria from oxidative stress while supporting neurotransmitter synthesis pathways

These medications are still relatively new

Mechanosensitive ion channels may also be involved in the early embryo-uterus crosstalk, as suggested by the high functional expression of the mechanosensitive PIEZO1 channels in epithelial cells of both mouse and human endometrium [40]

Intramedullary MSs (IMSs) are even rarer lesions, with only 12 cases of IMSs reported in the literature as of 2022