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This effect has been previously demonstrated in an infant rat model of pneumococcal meningitis 17 and in whole blood cultures from human patients with acute COVID-19 18

The insulinotropic and glucagon-suppressing effects of GLP-1 agonists directly address these goals, making them an established component of diabetes treatment algorithms

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In light of the substantial in vivo and in vitro evidence supporting the efficacy of GLP-1 RAs, further research into their protective mechanisms is imperative