Thus, our results not only have potentially important mechanistic implications in how both the oxidative and antioxidant arms of redox homeostasis cooperate to regulate cell survival and death, but also provide a promising therapeutic strategy for cancer patients harboring oncogenic RAS that warrants further translational and clinical investigation
5.1.6 MS-based proteomics: advanced techniques for studying protein oxidation Redox proteomics continues to advance, offering increasingly detailed insights into protein structure, dynamics, and modifications under oxidative stress
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Collectively, these data support the conclusion that increased cellular GSSG accumulation in hepatocytes plays a critical role in the pathogenesis of NAFLD and may represent a potential therapeutic target for the treatment of NAFLD
