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In 1933, phlorizin was found to completely inhibit renal glucose reabsorption, highlighting its potential to regulate blood glucose

Common side effects include nausea, diarrhea, and vomiting, especially when treatment begins

The Phase III trials have been testing tirzepatide as monotherapy, as an add-on to other treatments, and against established glucose-lowering drugs in people with T2D, as well as a weight-loss agent in people with diabetes and obesity

Most people can realistically expect 1525% weight loss over one year if they reach therapeutic doses and make concurrent lifestyle changes

Miracles up to a point

Plan for the Transition and Manage Expectations Gradual tapering Tapering refers to slowly decreasing your dose this is typically recommended over stopping GLP-1 medication abruptly