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Adverse Effects and Long-Term Safety Concerns While GLP-1 receptor agonists have shown significant benefits, their widespread use is limited by potential side effects such as gastrointestinal distress, pancreatitis risk, and concerns over long-term metabolic effects

That is the biological rationale behind the question, though the article is careful to separate rationale from proof

282 In strips of human skeletal muscle, GLP-1 promoted glycogen synthesis and inhibited glycogen phosphorylase activity- comparable findings were generated with L6 myotubes treated with GLP-1, as insulin-stimulated glycogen synthesis was increased

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Results demonstrated a remarkable 4.4kg decrease observed within just four weeks of treatment