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Primary endpoint Percentage weight loss at M6 was statistically significantly higher in the GLP-1-RA group than in the UCWM group (12.0% [3.3] vs

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Hence, because some of the cardiovascular benefits of SGLT2is are related to their hemodynamic effects, while those of GLP-1RAs are mainly related to their anti-atherogenic/anti-inflammatory actions, the two classes of medications may produce an additive cardiovascular benefit [11]

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These changes result from improved skin function, not from altering melanin activity