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Interestingly, evidence from preclinical models supports a functional link between intestinal bitter taste receptor (BTRs) and gastrointestinal hormone secretion, and the outcomes of recent studies indicate that stimulation of intestinal BTRs may be used to modulate gastrointestinal function, to diminish energy intake and limit postprandial blood glucose excursions in humans

doi:10.1111/j.1432-1033.1993.tb17986.x 27

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Goat anti-mouse Alexa Fluor 555 (AB_2535844), anti-rabbit Alexa Fluor 555 (AB_2535849), anti-rabbit HRP-conjugated secondary antibodies (AB_10960844), and DAPI were purchased from Thermo Fisher Scientific (Waltham, MA, USA)