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Results May Vary: Individual results will vary based on factors including age, baseline condition, lifestyle factors, dietary habits, physical activity levels, consistency of use, genetic factors, current medications, and other individual variables

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Certain gut microbes can synthesize and secrete gamma-aminobutyric acid (GABA) (64)

however, it enhances patient safety and provides an additional tool to guide anesthetic management

PMID: 22187690 31

Of course I have seen the reverse too, but when there is dietetic, psychological and physician oversight, there is a much better chance of success. For those who do experience rebound weight gain after weight-loss medication, surgery may be an option