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Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)
Research Evidence Comparison# Survodutide Research# Survodutide's clinical evidence is growing but remains primarily Phase 2: Phase 2 obesity trial : Randomized, dose-ranging study demonstrated up to 18.7% body weight loss at 46 weeks with the 4.8 mg dose, with dose-dependent efficacy across all arms Phase 2 MASH trial : Demonstrated significant reductions in liver fat content measured by MRI-PDFF, with histological improvement in MASH activity scores including inflammation and ballooning
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