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Tirzepatide delivered the greatest reduction, lowering HbA1c by an average of 2.3 percentage points

In summary: Survodutide (BI 456906) is an investigational GCGR/GLP-1 dual agonist being developed globally by Boehringer Ingelheim (under license from Zealand Pharma), now in Phase 3 for obesity with compelling Phase 2 weight-loss data that support its differentiation from existing GLP-1 therapies and strong potential across cardiometabolic indications

Mounjaro is the UK-licensed brand, mainly used for type 2 diabetes, but now being rolled out for obesity treatment through NHS specialist services

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GLP-1 Metabolic Optimization Protocol - Supplement Package

At the time of writing (October 2024), the primary recommendation comes from ANZCAs Clinical Practice Recommendation On Periprocedural Use Of GLP-1/GIP Receptor Agonists