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doi: 10.3389/ijph.2023.1605526 21
However, retatrutide may have superior benefits for insulin resistance and glycemic regulation , due to: Enhanced insulin sensitivity from GIP agonism Reduced hepatic glucose output from glucagon signaling modulation Improved beta-cell function Clinical Insight: Retatrutide reduced fasting glucose and A1C levels with similar or better efficacy than tirzepatide in early trials
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10.1523/JNEUROSCI.0345-16.2016 55
Casta-Abad MT, Godoy P, Bertran S, Montserrat-Capdevila J, Ortega M
Renal GLP-1 resistance, associated with attenuated natriuretic responses to GLP-1 has been observed in subjects with T2D (40, 41)
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