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Their primary ingredient is Semaglutide, which is the synthetic form of the hormone Glucagon-like-peptide-1 (aka GLP-1)

Mol Biol Cell (2001) 12(3):68598

In studies of GLP-1RA therapy in individuals with type 2 diabetes, the most frequently reported adverse events tend to involve the gastrointestinal system, with nausea, vomiting, and diarrhea occurring in up to 51%, 19%, and 20% of patients, respectively [44]

As of March 2026, retatrutide is an investigational drug in Phase 3 clinical trials