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J Clin Endocrinol Metab 89:55355541 Lynn FC, Thompson SA, Pospisilik JA et al (2003) A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells
GLP-1 receptor agonists work by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through action on brain appetite centres
Remember - increasing your bodys own GLP-1 hormone is helping increase post-meal satisfaction, decrease appetite (so you are better able to control your portions), and help you keep your blood sugar level all leading to healthy, sustainable fat loss, not to mention prevention of metabolic syndrome and diabetes
Doctors worry about the slow stomach emptying from GLP-1 medications and its effect on aspiration during anesthesia
Considering that and -cells express GIPR (224) and that the GIP-potentiating activity of Xenin has been reported to be lost in human diabetics (223), it appears to be a critical player in this disease, likely involving the activity of GLP-1
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