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Statistical significance was tested by Oneway ANOVA

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Furthermore, blocking NNMT also increases intracellular SAM (s-adenosylmethionine) levels, which may affect epigenetic regulation and promote energy expenditure and inhibit fat synthesis in adipocytes

Originally developed as a tanning agent (acting via MC1R receptors), it also binds to melanocortin receptors in the brain (particularly MC3R and MC4R) that influence sexual function

Bethel, M