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GLP-1 RAs have pleiotropic actions, with intervention on multiple regulation mechanisms

The list price for popular GLP-1 drugs is roughly $1,000 to $1,200 for a month's supply or $12,000-plus per year

130 Rhythm PharmaceuticalsI

Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy

Ljungdahl, P

A 2020 systematic review and meta-analysis published in Clinical Nutrition ESPEN (Asbaghi et al., pooling 12 randomized controlled trials) reported a statistically significant weighted mean reduction of 2.07kg in body weight, 0.47 kg/m in BMI, and 1.08cm in waist circumference compared to placebo