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While packaging itself is only one part of the system, it plays an essential role in enabling cold chain execution

Positioning of ThDP-dependent 2-oxo acid dehydrogenase complexes at the intersections of major pathways of central metabolism and transcriptional regulation endows these systems with a functional role of signaling hubs, regulating multiple cellular processes, such as intracellular redox status, growth, protein signaling, and calcium homeostasis (5052)

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It performs various physiological roles during exercise and has attracted strong interest in recent years with numerous investigations focused on increasing its intramuscular content to optimize its potential ergogenic benefits