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On the basis of the biological plausibility and anecdotal case reports of clinical improvement, (in)GSH has been recommended as an off-label therapy for GSH augmentation in PD since 2004

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In experiments with normal dermal fibroblasts, AHK was observed to apparently boost both cell growth and viability, alongside enhancing collagen type I production

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It adds that early improvement more likely reflects reduced inflammation than any structural change in cartilage, which develops far more slowly