NEJM STEP 1 (fulltext) samt versikt i PubMed STEP 1 (sammanfattning)
Effective transdermal delivery would require advanced technologies such as: Microneedle arrays : Tiny needles that create microscopic channels in the skin to facilitate drug absorption (these are minimally invasive devices rather than traditional patches) Chemical penetration enhancers : Substances that temporarily increase skin permeability Iontophoresis : Using electrical currents to drive charged molecules through the skin Nanoparticle formulations : Encapsulating drugs in carriers designed to cross skin barriers Several preclinical and early-stage studies have explored these approaches for GLP-1 delivery, with some promising results in laboratory and animal models
If semaglutide were swallowed in a standard pill form, stomach acid and digestive enzymes would destroy most of the medication before it could enter the bloodstream
F.VergariE.ZhangQ.ClarkA
One such substance, LY3437943, has been discovered to exhibit vigorous agonist activity on three distinct receptors, including the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors
By targeting blood sugar control, weight management, and cardiometabolic parameters, it addresses multiple aspects of metabolic dysfunction