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Clinically, RBC transfusion efficacy is monitored using hemoglobin increments, a surrogate measure, and transfusions are guided by threshold hemoglobin values or the extent of surgical blood loss

Similarly, the methylated derivative of resveratrol, pterostilbene, has been observed to upregulate Nrf2, HO-1, GSH, and GPX4 while reducing ACSL4 expression and iron content in H 2 O 2 -treated COV434 and KGN cells, suggesting a potential anti-ferroptotic effect ( In addition to the Nrf2/HO-1/GPX4 pathway, other pathways have been implicated

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Routine inflammatory markers (hsCRP, ferritin) and skin/symptom monitoring provide useful clinical checkpoints during a KLOW protocol

Souma, T