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In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation

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aeruginosa receiving NAC (2,400 mg/day, 4 weeks) showed improved serum antioxidants, reduced oxidative stress, and better FEV 1 % than controls (109)

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However, establishing causality in pharmacovigilance is inherently challenging, as temporal association does not prove causation

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