Its usually used for three to six weeks, although it is approved by the U.S
Collagen is almost always derived from animal by-products , such as the skin, bones or connective tissue of cattle, pigs or fish
We evaluated heterogeneity for the primary outcomes based on the agreement between CIs and prediction intervals in relation to the null effect and the clinically important effect on the opposite direction to the point estimate [16, 17]

and patients with pernicious anemia who have optic neuropathy COBALAMIN (Vitamin B12) Deficiency Causes Vegetarians (dietary deficiency) Older adults: atrophic gastritis affects 10% 30% and leads to decrease in hydrochloric acid secretion in the stomach and decreased absorption of Vitamin B12 The liver can store up to six years worth of Vitamin B12 so deficiencies are rare Effects of deficiency Megaloblastic anaemia (pernicious anaemia) Progressive demyelination of nerve cells Elevation in levels of circulating homocysteine that leads to production of defective collagen and elastin with a negative impact on arteries, bone and skin Deep vein thrombosis is associated with homocysteinemia that causes the activation of the intrinsic coagulation cascade Symptoms include fatigue, weakness, constipation, loss of appetite and weight loss Numbness, tingling of the feet imbalance, depression, confusion, dementia, poor memory and glossitis

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Curr Opin Hematol 13(3):175181 Chang EI et al (2007) Hypoxia, hormones, and endothelial progenitor cells in hemangioma