It is an enzyme that terminates the cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine (Ach)
20 TECOS (2015) did not show an increased risk of HF in patients taking sitagliptin for treatment of type 2 diabetes
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Current investigations span MASH, CKD, and heart-failure prevention, underscoring the pleiotropic potential of this drug
On the skin side, pallor, a yellowish tinge, dryness, hyperpigmented patches (particularly on the hands or face), and mouth or tongue soreness are classic signs
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