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NAPQI, due to acetaminophen ingestion, binds to and inhibits glutathione synthetase, reducing glutathione production

Department of Health & Human Services (HHS) Secretary Robert F

10.1371/journal.pone.0191573 58 KeshM.GoelS

In contrast to earlier assumptions, this generation of protein adducts can take place before GSH levels are depleted extensively [15,23] and also after therapeutic doses of APAP without relevant GSH depletion [15,16]