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Phase I: Transformation In the first phase, the liver uses enzymes to begin breaking down fat-soluble toxins into intermediate forms

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ABX-only) Design Type (ABX-only): A low-biomass background was established using an antibiotic cocktail in drinking water for 4 weeks to observe THH efficacy under microbiota-depleted conditions (Zheng et al., 2023) Results showed that the ameliorative effects of THH on joint swelling, inflammatory response, and bile acid metabolism abnormalities were significantly weakened or abolished after microbiota depletion (Zheng et al., 2023)

Diamond L.E., Earle D.C., Heiman J.R., et al