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Although substances that increase energy expenditure have existed, their clinical use has been limited due to safety concerns

Non-Diabetic Eligibility and Health Conditions Non-diabetic candidates for GLP-1 therapy typically have a body mass index (BMI) of 27 kg/m or higher with weight-related conditions, or a BMI of 30 kg/m or higher without comorbidities

Medical evaluation is essential before considering therapy

Promising preliminary data have suggested that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have a neuroprotective effect against PD, potentially slowing the progression of PD and helping patients maintain their motor function

[15] [16] Limitaciones de la evidencia actual incluyen: La mayora de los datos provienen de anlisis post-hoc o secundarios Dificultad para separar efectos antiinflamatorios directos de aquellos mediados por prdida de peso Seguimiento limitado a largo plazo (la mayora de estudios duran 40-72 semanas) Falta de estudios en poblaciones con enfermedades inflamatorias primarias Se necesitan ensayos clnicos prospectivos especficamente diseados para evaluar completamente el potencial antiinflamatorio de la tirzepatida y determinar su relevancia clnica

After extended outages, evaluate peptide appearance before use