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This framework should be regarded as a conceptual and hypothesis-generating model rather than a validated causal pathway because current human evidence remains heterogeneous in methodology, population, endpoint definition, and follow-up duration

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Leite JS, Raizel R, Hyplito TM, Rosa TD, Cruzat VF, Tirapegui J

Also, individuals with pre-existing thyroid disorders are considered more susceptible to potential adverse effects of excess iodine (either hypo or hyperthyroidism) [5, 22]