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If administered by injection, local reactions such as redness, swelling, itching, or pain can occur, and improper technique can increase infection risk

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Start with once or twice a week, and gradually increase frequency to every other night for best results

Notably, the diabetes prevalence in adults under 40 has risen twofold, prompting national guideline revisions that lowered the recommended age for routine screening from 40 to 35 years (Gao et al., 2025

Caution should be used in patients with long-standing diabetes with neuropathy and gastroparesis, as well as incompletely treated diabetic retinopathy