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Given that glutathione is the most abundant thiol in the mitochondria 36, 37 , it is no surprise that ETHE1 exhibits high specificity for glutathione persulfide as its substrate

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ATTAIN-1 was a 72-week, randomized, double-blind, placebo-controlled trial comparing the efficacy and safety of orforglipron (6 mg, 12 mg, and 36 mg) as monotherapy vs