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THERAPEUTIC INTERVENTIONS CLINICAL EXAMPLES AND THERAPEUTIC FORMS: N-acetylcysteine (NAC) Improving cellular glutathione status remains a clinical challenge, though interventions which enhance glutathione synthesis have for the most part been successful, most notably N-acetylcysteine (NAC)

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DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

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Experiments based on kinetic and chemical modification techniques indicated that the active site might contain either His, Cys, Trp, Arg, or Asp [1721]

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