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J Am Chem Soc 128: 1078410794

The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial

At present, the lack of large-scale, confirmatory clinical trials specifically targeting MC4R deficiency is largely due to significant scientific and clinical heterogeneity, which has made conducting such trials logistically challenging and commercially less appealing compared to pursuing broader or more clearly defined patient populations

The specificity of the response was determined by treatment with an IGF-1R specific inhibitor, Picropodophyllin (PPP) that showed reduced BCL2 levels in GNE knockdown cells indicative of apoptotic response (Fig

G.et al (2000b)