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Limitations and Research Status While preclinical data is extensive, large-scale human clinical trials are limited

Two takeaways apply to both peptides: Read the label on every vial

Never adjust GLP-1 dosing on your own without explicit provider approval during acute illness

For three times weekly at the same 8mg target, each injection is approximately 2.67mg, which equals about 0.53mL or 53 units

BMJ, 341, c3666

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use