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During the titration period, doses of metformin were increased up to 2,000 mg/day

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The same modifications produce the extended plasma half-life (~2030 h) that distinguishes LR3 from native IGF-1 (~1020 min) in animal studies

Thus, this mechanism, which avoids excessive nutrients, achieves metabolically active organs with a gain in insulin sensitivity and weight loss, providing long-lasting effects, unlike drugs, that act only in a weight-dependent manner (23)