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This issue is clearly illustrated by Politi et al., who investigated omega-3 supplementation in a cohort of young adults with severe autism and profound intellectual disability, reporting no behavioral benefits

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Since the liver has an abundant vascular structure and peripheral lymph distribution, ICC is prone to intrahepatic and extrahepatic metastases, and distant metastasis occurs in 70% of clinical autopsies ( Radical surgical resection is currently the only possible curative method for ICC, with a 5-year survival rate of about 30% and a 5-year recurrence rate of 60%70% ( Conclusions ICC with rectal metastasis is a rare mode of distant metastasis that may pose a diagnostic challenge

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