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doi: 10.1016/j.cmet.2018.05.006 61

The hormone-aware metabolic framework describes a structured sequence for metabolic intervention: stabilizing hormonal conditions first, calibrating GLP-1 dosing second, accelerating metabolic improvement through monitoring and titration, and preserving lean mass throughout the process

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Several studies have reported an inverse relationship between BMI and therapeutic efficacy, indicating that obesity may attenuate clinical responses to biologic disease modifying anti-rheumatic drugs (bDMARDs)