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Curcumin increases Nrf2 expression and its downstream targets HO-1 and GPX4 in hepatocytes, 452 cardiomyocytes, 504 neurons, 679 renal tubule cells 865 and chondrocytes, 882 protecting against diseases by inhibiting ferroptosis

(2016a)

This mechanism contributes to the attenuation of neuronal damage (He et al., 2023)

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Nature 402:685689 Rubi B, Ishihara H, Hegardt FG, Wollheim CB, Maechler P (2001) GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells