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These improvements typically become noticeable after 48 weeks of consistent dosing as the medication reaches steady-state levels

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Mounjaro Dosing Progression Weeks 1-4: 2.5 mg weekly (starter dose) Weeks 5-8: 5 mg weekly Weeks 9-12: 7.5 mg weekly Weeks 13-16: 10 mg weekly Weeks 17-20: 12.5 mg weekly Weeks 21+: 15 mg weekly (maximum dose) Mounjaros titration schedule is longer and involves more dose steps

This can help break the pattern

Edgar et al., 2012

The phase 2 trial showed that the 12mg group lost 24.2% of body weight at 48 weeks versus 8.7% in the 1mg group