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Surgical management is indicated for progressive scoliosis or progressive joint pain not responsive to non-operative management

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Retatrutide operates by targeting hormone receptors connected to appetite and blood sugar

GLP-1s directly mimic a hormone that regulates appetite and insulin, while berberine works through multiple pathways, including AMPKL activation and by tweaking the gut microbiome

Seek immediate medical attention (call 999) for severe chest pain, sudden severe breathlessness, or loss of consciousness

Mechanistically, TMAO may contribute to electrophysiological dysfunction by activating the protein kinase R-like endoplasmic reticulum kinase (PERK)/IRE1 axis, leading to increased atrial remodeling and subsequent arrhythmogenesis [62]