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Jason Brett, principal US medical head for Novo Nordisk, told CNN in an interview

Because she meets obesity criteria and has an additional metabolic risk factor, she would generally be considered a strong candidate for evaluation

Similarly, if injection site reactions become progressively worse rather than improving, show signs of infection (increasing warmth, spreading redness, pus, or red streaking), or fail to resolve within several days, medical assessment is warranted

Lillys Taltz (Ixekizumab) and Zepbound (Tirzepatide) Used Together Delivered Superior Efficacy in First-of-Its-Kind Phase 3B Trial for Adults With Active Psoriatic Arthritis and Obesity or Overweight

The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]