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The first GLP-1 was FDA approved in 2005 as a twice-daily injection indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2DM (these products are not approved for those with type 1 diabetes)

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Imai H, Hirao F, Sakamoto T, Sekine K, Mizukura Y, Saito M et al (2003) Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

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